2005年～2023年

論文名 著者 会誌 年

The effectiveness of goreisan,for gestational edema and

amniotic fluid decrease —Review—

Fukashi Makimoto

Traditional&Kampo medicine

2023.p1-5

https://doi.org/10.1002/

           tkm2.1366

 2023

妊娠中の漢方

羊水減少に五苓散が効く

槇本　深

秋山　實男

渡辺　員支

西岡　嘉宏

漢方と最新治療

2019;28 99-105

 2019

The therapeutic effect of goreisan to oligohydramnios.
–Gorei-San increase the single deepest pocket in

oligohydramnios–

Fukashi Makimoto,

Kazushi Watanabe,

Takahisa Ushiroyama,

Jitsuo Akiyama,

Kazuhiko Tsuji,

Kayo Tsuji,

Toru Yoshikawa,

Yoshihiro Nishioka,

Toshiaki Endo,

Hypertension

Research in Pregnancy

2016;4:24-29

 2016

The change of the Amniotic Pockets by the Wu-Ling-San

treatment for gestational edema.

Fukashi Makimoto,

Jitsuo Akiyama,

Kenichiro Sato,

Kazushi Watanabe,

and Takahisa Ushiroyama,

Am J Chin Med.

2013;41:293-9

 2013
Examination of treatment effect for pregnancy
edema of goreisan to assume a weight increase to
be index.		 Fukashi MAKIMOTO,
Seikichi KINJOU,
Kaori KUKUTA,
Toru YOSHIKAWA,
Jitsuo AKIYAMA,
Hiromichi YASUI.		 Journal of Kampo Medicine
2009 English Edition.
18-22,2009.		 2009
Examination of treatment effect for
pregnancy edema of goreisan to assume
a weight increase to be index.

Fukashi MAKIMOTO,

Seikichi KANESHIRO,

Kaori KIKUTA,

Toru YOSHIKAWA ,

Jitsuo AKIYAMA

J Kampo

Medicine(English Edition)

2009;1:18-22.

 2009
体重増加を指標とした五苓散の妊娠浮腫治療効果の検討

槇本深,金城誠吉,

菊田香織,吉川徹,

秋山實男

漢方の臨床

2008;55:1003-1011

 2008
3-Nitropropionic acid-induced membrane
permeabirity transition of isolated mitochondria
and its suppression by L-carnitine		 Hirofumi　Fujita,
Yuya Okimura,
Tetsuya Ogino,
Hiromi Yano,
Kozo Utsumi,
Junzo Sasaki		 Physio. Chem.&Physics
and ed. NMR,in preparation,
2008.		 2008
フローサイトメーターによる微量ミトコンドリアの
機能解析		 沖村祐弥、藤田洋史、
阿部浩一、矢野博己、
秋山實男、内海耕慥、
佐々木順造		 ビタミンE研究の進歩XⅢ 2008
Alpha-Lipoic acid suppresses
6-hydroxydopamine-induced ROS generation and
apoptosis through the stimulation of
Nrf2/glutathione pathway but not by the expression
of heme oxygenase-1		 Hirofumi Fuzita,
Masahiro Shiosaka,
Tetsuya Oginob,
Yuya Okimura,c,
Toshihiko Utsumi,
Eisuke F.Sato,
Reiko Akagi,
Masayasu Inoue,
Kozo Utsumi
and Jinzo Sakaki		 Brain Res.In press,2008. 2008
Regulation of 5-aminolevulinic acid-dependent
protoporphyrin IX accumulations in human
histiocytic lymphoma U937 cells		 Yuya Okimura,
Hirofumi Fujita,
Tetsuya Ogino,
Keigi Inoue,
Hiromi Yano,
Tatsuji Yasuda,
Masayasu Inoue,
Kozo Utsumi
and Junzo Sasaki		 Physio. Chem. &Physics and
ed.NMR39,in press,2008.		 2008
Flow cytometric Analysis of Ca２＋Induced
Membrane Permeability Ttransition of Isolated Rat
Liver mitochondria		 Taruo Umegaki,
Yuya Okimura,
Hirofumi Fujita,
Hiromi Yano,
Jituo Akiyama,
Masayasu Inoue,
Kozo Utsumi
and Junzo Sasaki		 Clinikal Biochemistry and
Nutrrition, 42, 35-44,2008.		 2008
Regulation of 5-aminolevulinic acid-mediated
protoporphyrin IX-accumulation and its
photodynamic action in U937 cells		 HIrofumi Fujita,
Yuya Okimura,
Tetsuya Ogino,
Tatsuji Yasuda,
Koichi Abe,
Kozo Utsumi
and Junzo Sasaki.		 J.Clinical Biochemistry and
Nutrition 41,Suppl.
P143．2007		 2007
Role of □-lipoic acid on mitochondorial functions,
redox metabolism and apoptosis of cells		 Hirofumi Fujita,
Youya Okimura,
Toshihiko Utsumi,
Eisuke Sato,
Kozo Utsumi,
Junmzo sasaki,
and Junzou Sasaki		 J.Clinical Biochemistry and
Nutrition 41, Suppl.
P139．2007		 2007
酸化ドパーミン誘導性アポトーシスに対する
Antioxidant biofactor (AOB)の阻害作用における
GSH合成の関与		 藤田洋史、荻野哲也、
内海耕慥、佐々木順造		 医学と薬学
58,417-424，2007.		 2007
Mechanism of A23187-induced apoptosis in HL-60
cells:dependency on mitochondrial permeability
transition but not NADPH oxidase		 Noriko kazitani,
Hirotsugu Kobuchi,
Hrofumi Fujita,
Hirofumi Yano,
Takuzo Fujiwara,
Tatsuji Yasuda
and Kozo Utsumi		 biosci. Biotechnol.
Biochem.
71,2702-2711,2007.		 2007
αリポ酸と細胞死. 藤田洋史、沖村祐弥、
佐藤英介、内海耕慥、
佐々木順造		 New Food Industry,
49,2007		 2007
Stimulation of membrane permeability transition
by alpha-lipoic acid and its biochemical
characteristics		 Aoyama S, Okimura Y,
Fujita H,Sato EF,
Umegaki T,Abe K,
Inoue M, Utsumi K,
Sasaki J.		 Physiol Chem Phys Med
NMR.38.1-20.2006．		 2006
Flow cytometric analysis of Ca2+ -induced
membrane permeability transition of mitochondria		 Yuya Okimura,
Hirofumi Fuzita,
Hiromi Yano,
Jitsuo Akiyama,
Kozo Utsumi
and Junzo Sasaki		 Clinical Biochemistry and
Nutrition 39, 2006,
Submitted.		 2006
Mechanism of 3-Nitropropionic acid-induced
membrane permeability transition and its
suppression by L-carnitine		 Teruo Umegaki,
Hirofumi Fujita,
Yuya Okimura,
Jitsuo Akiyama,
Hiromi Yano,
Kozo Utsmi
and Junzo Sasaki		 Clinical Biochemistry and
Nutrrition 39, 2006,
Submitted.		 2006
αリポ酸と細胞死 藤田洋史、沖村祐弥、
佐藤英介、内海耕慥、
佐々木順造		 New Food Industry, 49,2007 2006
Stimulation of membrane permeability transition by
α-lipoic acid and its biochemical characteristics		 Sanae Aoyama,
Yuya Okimura,
Hirofumi Fujita,
Eisuke F.Sato,
Koichi Abe,
Masayasu Inoue,
Kozo Utsumi
and Junzo Sasaki		 Physiol,Chem.&Physics and
Med. NMR, 2006, In press.		 2006
6-ｈｙｄroxydopamineによるPC12細胞のｱﾎﾟﾄｰｼｽと
αリポ酸ラセミ体（ALIPURERR））による抑制機構		 藤田洋史、沖村祐弥、
青山早苗、秋山實男、
井上俊忠、井上正康、
内海耕慥、佐々木順造		 医学と薬学　
55,857-866，2006.		 2006
アポトーシスとミトコンドリア　 特集ミトコンドリア病、 藤田洋史、小渕浩嗣、
内海耕慥		 Crinical Neuroscience
(中外製薬)
24（6）、463-467、2006		 2006
Cell-permeable cAMP analog suppresses
6-hydroxydopamine-induced apoptosis in PC12
cells through the activation of the Akt pathway.		 Fujita H,Ogino T,
Kobuchi H,Fujiwara T,
Yano H, Akiyama J,
Htsumi K.		 Brain Res.
1113, 10-23,2006.		 2005
4-OH-3,5,3′,4′-Tetrachlorobiphenyl induced
membrane permeability transition in isolated
mitochondria		 Hirofumi Fujita,
Yuya Okimura,
Takuzo Fujiwara,
Toshihiko Utsumi,
Shigeyuki Kitamura,
Hiroaki Kuroki,
Akihiko Kashiwagi
and Kozo Utsumi.		 Clinical Biochemistry and
Nutrition 38, 167-175, 2006.		 2005
Mechanism of 6-hydroxydopamine-indukuced
apoptpsis of PC12 cells:dependency on reactive
oxygen species,p-38,Bid, and caspase pathway
but not membrane permeability transition.		 Fijita H,Ogino T,
Kobuchi H,Yano H,
Yorimitsu M,Akiyama J,
Utsumi K.		 J.Neurochem.
(2005),Submitted		 2005
The Response of Human T Lymphocytes Against
Alloantigens Following Fas-Mediated
Activation-Induced Cell Death		 Fujita T, Fujita H,
Muranaka S, Utsumi K,
Kusaka H, Hamasaki K		 Transplant. Proceed.
(2005)37,46-48		 2005
A possible Site of Superoxide Generation in the
dependent ROS Generation in Undifferentiated		 Ohnishi T, Ohnishi T,
Mutanaka S, Fujita H,
Kimura H, Uemura K,
Yoshida K, Utsumi K.		 J Bioener. And Biomem.
(2005)37(1),1-15		 2005
Mechanism and Characteristics of
Stimuli-dependent ROS Generation in
Undifferentiated Hl-60 cells.		 Muranaka S,Fujita H,
Fujiwara T, Ogino T,
Sato EF, Akiyama J,
Imada I, Inoue M,
Utsumi K.		 Antioxid.&Redox Signal.
(2005)7,1367-1376		 2005
Involvement of Ras/extracellular signal-regulated
kinase,but not Aktpathway in risedronate-induced
apoptosis of U937 cells and its suppression by
cytochalasin B.		 Fujita H, Utsumi T,
Muranaka S, Ogimo T,
Akiyama J, Yasuda T,
Utsumi K.		 Biochem. Pharmacol.
(2005)69,1773-1784		 2005
羅布麻抽出物（ベネトンR）の抗酸化作用と
その解析		 藤田洋史、沖村祐弥
内海俊彦、竹原良記
藤原拓造、秋山實男
妹尾修次郎、内海耕慥		 医学と薬学54（4）：
491-503,2005		 2005
ｵﾘｰﾌﾞ水溶性抽出物HidoｘTMの抗酸化作用と
その解析		 藤田洋史、竹原良記
村中式部、依光正枝
沖村祐弥、藤原拓造
秋山実男、内海耕慥		 医学と薬学 54（2）：
195-202,2005		 2005
6-ｈｙｄroxydopamineによるPC12細胞のｱﾎﾟﾄｰｼｽと
その抗酸化AOBによる抑制		 藤田洋史、竹原良記
村中式部、依光正枝
沖村祐弥、藤原拓造
秋山実男、内海耕慥		 医学と薬学 54（2）：
195-202,2005		 2005

2000年～2004年

論文名 著者 会誌 年
ミトコンドリア膜透過性遷移における
酸化的ストレスとＶＥの関与		 依光正枝、菅野智子、
村中式部、藤田洋史、
玉井　浩、佐藤英介、
井上正康、内海耕慥		 ビタミンＥ研究の進歩
（2004）11		 2004
アクトネル（リセドロネート）によるＵ９３７細胞の
アポトーシスとその機構		 藤田洋史、菅野智子、
内海俊彦、村中式部、
藤原拓造、宮口長青、
秋山実男、保田立二、
内海耕慥		 医学と薬学
（2004）51,697-710		 2004
Involvement of Ras/ERK,but not Akt pathway in
risedronate-induced apoptosis of U937 cells and
its suppression by cytochalasin B.		 Fujita H, Utsumi T,
Muranaka S, Ogino T,
Yano H, Akiyama J,
Yamada T and Utsumi K.		 Biochemical Pharmacoliogy
(2004)Submitted.		 2004
Mechanism and characteristics of stimuli-dependent
ROS generation in undifferentiated HL-60 cells.		 Muranaka S, Fujita H,
Fujuwara T, Ogino T,
Sato E.F, Akiyama J,
Imada I, Inoue M
and Utsumi K.		 Antioxidants & Redox
Signaling (2004)		 2004
Role of a α-tocopherol in mitochondrial membrane
permeability transition.		 Yorimitsu M, Kannno T,
Muranaka S, Sato F.E,
Fjiyama T, Imada I,
Yasuda T, Inoue M
and Utsumi K.		 Physiol. Chem. Phys. &　
Med. NMR. (2004)Sumitted.		 2004
Molecular mechanism of diclofenac-induced
apoptosis of promyelocytic leukemia:dependency
on reactive oxygen species,Akt,Bid,cytochrome c
and caspase pathway.		 Inoue A, Muranaka S,
Fjita H, Kanno T,
Tamai H and Utsumi K.		 Free Radic. Biol. Med.
(2004)37,1290-1299.		 2004
17β-Estradiol suppresses ROS-induced
apoptosis of CHO cells through inhibition of lipid
peroxidation-coupled membrane permeability
trasition.		 Miyaguchi C, Muranaka S,
Kannno T, Fujita H,
Akiyama J, Yoshioka T
and,Yasuda　T.		 Physiol .Chem. Phys.
&Med.NMR.(2004)In press.		 2004
Role of a α-tocopherol in the regulation of
mitochondrial membrane permeability transition.		 Kannno T, Yorimitsu M,
Muranaka S, Sato E.F,
Nagano M, Inoue A,
Inoue M and Utsumi K.		 J.Clin. Biochem. Nutri.
(2004)35,7-15		 2004
Involvement of ceramide in the mechanism of
Cr(VI)-induced apoptosis of CHO cells.		 Muranaka S, Kannno T,
Fujita H, Kobuchi H,
Akiyama J,Yasuda T
and Utsumi K.		 Free Radic. Res.
(2004)38,613-621		 2004
Oxidative stress underlies the mechanism for
Ca2+-induced permeability transition of
mitochondria.		 Kannno T, Sato E.F,
Muranaka S, Fujita H,
Fujiwara T, Utsumi T,
Inoue M and Utsumi K.		 Free Radic. Res.
(2004)38,27-35		 2004
Cepharanthine,an anti-inflammatory
drug,suppresses mitochondrial membrane
permeability transion.		 Nagano M, Kanno T,
Fujita H, Muranaka S,
Fujiwara T and Utsumi K.		 Physiol. Chem. &Phys.
And Med. NMR.(2003),
in press.		 2003
Oxidative stress underlines the mechanism for
Ca2+-induced permeability transition of
mitochondria.		 Kanno T, Sato E.F,
Muranaka S, Fujita H,
Fujiwara T,Utsumi T,
Inoue M and Utsumi K.		 Free Radical Research
(2003), in press.		 2003
The effects of immunosuppressants on
Fas-mediated activation-induced cell death in
human T lymphocytes.		 Fujiwara T, Ikeda Y,
Arita K, Kanno T,
Takehara Y, Yabuki M
and Utsumi K.		 Transplant International
(2003),16,108-114		 2003
Cholesteryl-hemisuccinate-induced apoptosis of
promyelocytic　leukemia HL-60 cells through a
cyclosporin A-insensitive mechanism.		 Yamada K, Arita K,
Kobuchi H, Yamamoto S,
Yoshioka T, Tamai H
and Utsumi K.		 Biochemical Pharmacology　
(2003)65,339-348		 2003
Mechanisms of apoptosis in HL-60 cells by
UV-irradiated n-3 and n-6 polyunsaturated
fatty acids.		 Arita K, Yamamoto Y,
Takehara Y, Utsymi T,
Kanno T, Miyaguchi C,
Akiyama J,Yosioka T
and Utsumi K.		 Free Radic. Biol. Med.
(2003)35,189-199		 2003
Mitochondrial Swelling and Cytochrome
Release:Sensitivity to Cyclosporin A and Calcium.		 Kanno T, Fujita H,
Muranaka S, Yano H,
Utsumi T, Yoshioka T,
Inoue M and Utsumi　K．		 Physiol. Chem. &Phys.
And Med. NMR.
(2002)34in press.		 2002
Cholesteryl-hemisuccinate-induced apoptosis of
promyelocytic leukemia HL-60 cells through a
cyclosporin A-insensitive mechanism.		 Yamada K, Arita K,
Kobuchi H, Yamamoto S,
Yoshioka T, Tamai H,
Utsumi K.		 Biochemical Pharmacology　
2002　63,pre print.		 2002
The effects of immunosupprressants on
Fas-mediated activation induced cell death in
ｈuman T lymphocytes.		 Fujiwara T, Ikeda Y,
Arita K, Kanno T,
Takehara Y, Yabuki M
and Utsumi K.		 Transplant International
2002		 2002
Induction and mechanism of apoptotic cell death
by propofol in HL-60　cells.		 Tsuchiya M, Asada K,
Arita K, Utsumi T,
Yoshida T, Sato E.F,
Utsumi K and Inoue M.		 Acta. Anaesthesiol. Scand.
(2002)46,1068-1074		 2002
Ａ new ferrochelatase mutation combined with
low expression alleles in a Japanese patient with
erythropoietic protoporphyria.		 Yasui Y, Muranaka S,
Tahara T, Shimizu R,
Watanabe S, Horie Y,
Nanba E, Uezato H,
Takamiyagi A, Taketani S
and Akagi R.		 Clinical Science (2002）,
102,501-506		 2002
Effect of n-3 and n-6 polyunsaturated fatty acids
and their ethyl esters on stimulidependent
superoxide generation in neutrophils.		 Arita K, Kanno T,
Takehara Y, Fujiwaka T,
Akiyama J, Horton AA
and Utsumi T.		 Physiological
Chemistry&Physics
and Medical NMR,
in press.2001		 2001
Suppression of T3-and fatty acid-induced
membrane permeability transition by L-carnitine.		 Kashiwagi A, Kanno T,
Arita K, Ishisaka R,
Utsumi K.		 Comp BiochemPhys130:
411-418,2001		 2001
Roles of long chain fatty acids and carnitine in
mitochondrial membrane permeability transition.		 Furuno T, Kanno T,
Atita K, Asami M,
Utsumi T, Doi Y,
Inoue M and Utsumi K.		 Biochemical Prarmachology
62:1037-1046,2001		 2001
Activation of caspase-3 by lysosomal cystein
proteases and its role in
2,2′-Azobis-(2-Amidinopropane)
Dihydrochloride(AAPH)-induced apoptosis in
HL-60 cells.		 Ishisaka R, Kanno　T,
Akiyama J, Yoshioka T,
Utsumi K and Utsumi T.		 J Biochemical
129:35-41,2001		 2001
細胞質へのｼﾄｸﾛｰﾑC遊離の測定 石坂瑠美 新ﾐﾄｺﾝﾄﾞﾘｱ学
（監修：内海耕慥、井上正康）
共立出版		 2001
ミトｺンドリア依存性アポトーシスと膜電位 菅野智子、石坂瑠美、
内海耕慥		 新ﾐﾄｺﾝﾄﾞﾘｱ学
（監修：内海耕慥、井上正康）
共立出版		 2001
カルニチンとミトコンドリア機能障害 菅野智子、有田佳代、
内海俊彦、井上正康、
内海耕慥		 新ﾐﾄｺﾝﾄﾞﾘｱ学
（監修：内海耕慥、井上正康）
共立出版		 2001
Mechanism of apoptpsis in HL-60cells induced by
n-3 and n-6 polyunsaturated fatty acids		 Koyo Arita,
Hirotsugu Kobuchi,
Toshihiko Utsumi,
Yoshiki Takehara,
Jitsuo Akiyama,
Alan A.Horton,
Kozo Utsumi		 Biochemical Pharmacology
821-828，2001		 2001
好中球のｆMLP刺激依存性活性酸素生成の
ｸﾞﾘﾁﾙﾘﾁﾝによる特異的阻害作用		 菅野智子、宮口長青、
梶谷典子、山田勝彦、
秋山実男、吉岡　保、
内海耕慥		 医学と薬学：45（5）:
835-845,2001		 2001
Role of long chain fatty acids and cernitine in
membrane permeability transition of mitochondria
and apiptosis of HL-60 cells		 Takashi Furuno,
Tomoko Kanno,
Koyo Arita,
Maki Asami,
Toshihiko Utsumi,
Yoshinori Doi,
Masayasu Inoue
and Kozo Utsumi.		 Biochem. Pharmachol. 2000
Mechanism of apoptosis in HL-60 cells induced by
n-3 and n-6 polyunsaturated fatty acids.		 Kayo Arita,
Hirotsugu Kobuchi,
Toshihiko Utsumi,
Yoshiki Takehara,
Jitsuo Akiyama,
Masayasu Inoue
and Kozo Utsumi.		 Biochemical Pharmacology, 2000
α-tocoperyl succinate による
HL-60のアポトーシスとその機構		 山本真司、石坂瑠美、
山本真司、石坂瑠美、		 ビタミンE研究の進歩2000. 2000
Activation of caspase-3 by lysosomal cystein
proteases and its role in 2,2′
azobis-2- amidineopropane) dihydrochloride(AAPH)
– induced apoptpsis in HL-60 cells		 Rumi Isisaka,
Toshihiko Utsumi,
Tomoko Kanno,
Jitsuo Akiyama,
Tamotsu Yoshioka
and Kozo Utsumi.		 J.Biochem. 2000
Mechanism of dibucain-induced apoptosis in
promyelocytic leukemia cells (HL-60).		 Kayo Arita,
Toshihiko Utsumi,
Akio Kato,
Tomoko Kanno,
Hirotsugtu Kobudhi,
Bunji Inoue,
Jitsuo Akiyama
and Kozo Utsumi.		 Biochemical Pharmachology,
60, 905-915		 2000
Mechanism of α-tocopheryl succinateinducd
apoptosis of promyelocytic leukemia cells(HL-60).		 Shinji Yamamoto,
Hiroshi Tamai,
Rumi Ishisaka,
Tomoko Kanno,
Kayo Arita,
Hirotsugu Kobudhi
and Kozo Utsumi.		 Free Rad. Res.
33,407-418		 2000
Effects of a magnetic fields on the various
functions of subcellular organelle and cells.		 Rumi Ishisaka,
Tomoko Kanno,
Yoko Inai,
Hiriko Nakahara,
Jitsuo Akiyama,
Tamotsu Yoshioka
and Kozo Utsumi		 Pathophysiology
7,149-152		 2000
細胞質へのシトクロームC遊離測定 石坂瑠美 新ミトコンドリア学 2000
ミトコンドリア依存症アポトーシスと膜電位 菅野智子、石坂瑠美 新ミトコンドリア学 2000
カルシトニンとミトコンドリア機能病態 菅野智子、有田佳代、
内海俊彦、井上正康、
内海耕慥		 新ミトコンドリア学 2000
Suppresion of mitochondrial membrane
permeability transition by L-carnitin and its role
in apiptotic cell death.		 Tomoko Kanno,
Kayo Arita,
Toshihiko Utsumi,
Takashi Furuya,
Masayasu Inoue
and Kozo Utsumi.

In ‘Free Radicals in
Chemistry, Biology and
Medicine’.
OICA inter-national(UK)
Limited,London, PP-PP.

 2000

1994年～1999年

論文名 著者 会誌 年
Participation of a cathepsin L-type protease in the
activation of caspase-3.		 Rumi Ishisaka,
Toshihiko Utsumi,
Tmoko Kanno,
Kayo Arita,
Nobuhiko Katunuma,
Jitsuo Akiyama,
and Kozo Utsumi.		 Cell Struct.Funct. 26, 1999
Selective inhibition of
formyl-methionyl-leucyl-phenylalanine(fMLP)-
dependent superoxide generation on neutrophils by
pravastation,aninhibitor of 3-methyglutaryl
coenzyme A(HMG=CoA) reductase.		 Tomoko Kanno,
Kazuko Abe,
Munehisa Yabuki,
Jitsuo Akiyama,
Tatsuji Yasuda,
and Alan A Hortan.		 Bichem. Pharmacol. 58, 1999
Apart of the transmembrane domain of pro-TNF
can fanction sa a cleavable signal sequence that
genetates a biologically active secretory form of TNF.		 Rumi Ishisaka,
Noriyuki Sato,
Kenji Tanaka,
Tominori Takeshige,
Hiroyuki Iwata,
Jim Klostergaard,
and Toshihiko Utsumi.		 J.Biochem. 126,413-420 1999
The effect of milk and colostrum on superoxide
generation of oral polymorphonuclear leukocytes
and the changes that occur during storage at
low temoerature.		 Hiroshi Kanematsu,
Tomoko Kanno,
Hiroko Nakahara,
Rumi Ishizaka,
Jitsuo Akiyama,
Alan A Horton,
Tatsuji Yasuda,
and Tamotsu Yoshioka.		 Biol.Neonate. 76,331-339 1999
Tyroxine enhancement and the role of reactive
oxygen species in tadpole tail apoptosis.		 akihiko Kashiwagi,
hideki hanada,
Munehisa Yabuki,
Tomoko Kanno,
Rumi Isizaka,
Junzo Sasaki,
Masayasu Imoue,
and Kozo Utrsumi.		 Free Radic.biol.Med.
26,1001-1009		 1999
Resistance to nitric oxde-mediated apoptosis in
HL-60 variant cells is associated with increased
activities of Cu,Zn-superoxide dismutase and
catalase.		 Munehisa Yabuki,
Shinji Kariya,
Rumi Isizaka,
Tatsuji Yasuda,
Tamotsu Yoshioka,
Alan A Horton,
and Kozo Utrsumi.		 Free Radic.Biol.
26,325-332,		 1999
リソソームとアポトーシス 石坂瑠美、内海俊彦、
矢吹宗久、勝沼信彦、
内海耕慥		 生体の科学 50：117-126 1999
ビタミンＥによる人臍帯血好中球のＯ２生成阻害と
その機構		 吉岡保、安藤正明、
西内敏文、稲盛美香、
小林靖明、秋山実男		 日本産婦人科・
新生児学会誌8(1):34-41		 1998
The effect of milk and colostrum on the superoride
generation of oral neutrophils and its change during
storage at low temperature,		 Hiroshi Kanematsu,
Hiroko Nakahara,
Tomoko Kanno,
Rumi Ishioka,
Jitsuo Akiyama,
Aran A Horton
and Tamotsu Yoshioka,		 Biol. Neonant. 1998
Reactive oxygen species underlie the mechanism for
thyroxin-induced apoptosis in tadpole tail,		 Akira Kashiwagi,
Hideki Hanada,
Munehisa Yabuki,
Tomoko Kanno,
Rumi Ishioka,
Junzo Sasaki,
Masayasu Inoue
and Kozo Utsumi,		 FreeRad,Biol.Med. 1998

Isolation and characterization of HL-60 variant
cells resistant to nitric oxide-induced apoptosi .

 Munehisa Yabuki,
Shinji Kariya,
Rumi Ishioka,
Tatsuji Yasuda,
Tamotsu Yoshioka
and Kozo Utsumi,		 FreeRad,Biol.Med. 1998
両生類の変態における細胞死の分子機構
-水生から陸生への準備-
生命誕生と生物の生存戦略
（ヒ卜は何処から来て、何処に行くのか？）
井上正康、内海耕情監修		 柏木昭彦、花田秀樹、
矢吹宗久、菅野智子、
石坂瑠美、竹原良記、
佐々木順造、井上正康、
内海耕慥		 日本アクセル.
シュプリンガー出版		 1998
エネルギー代謝と活性酸素
運動と活性酸素(井上正康編)		 内海耕慥,菅野智子,
失吹宗久		 共立出版 1998
Superoxide Dismutase-Like Activity of Metal
Saturated Lactofeffin Derivatives		 Rumi Ishioka,
Tomoko Kanno,
Hiroshi Kanamatsu,
Toshihiko Utsumi,
Jitsuo Akiyama,
Tamotsu Yoshioka,
Alan A.Horton
and Kozo Utsumi		 Physiol, Chem. Phys.
& Med, NMR, in prcss,		 1998
Oxygen-dependent regulation of various biological
functions by nitric oxide in “Mitochondria, Oxidants,
and Aging”(ed. E.Cadenas and L.Packer)		 Kozo Utsumi,
Yoshih Takehara,
Tomoko Kanno,
Yoko Inai,
Munehisa Yabuki,
Tamotsu Yoshioka,
Eisuke F.Sato,
Manabu Nishikawa
and Masayasu Inone		 Marcel Dekker Inc. 1998
Oxygen concentration regulates NO-dependent
relaxation of rat aortic smooth muscle,		 Yoshiki Takehara,
Yoko Inai,
Hiroko Nakahara,
Munehisa Yabuki,
Keisuke Hamazaki,
Tamotsu Yoshioka,
Tatsuji Yasuida,
Masayasu Inoue
and Kozo Utsrmi`		 FreeRad`Res. inpress, 1998
Biochemical properties of human oral
polymorphonuclear lenkocytes		 Hiroko Nakahara,
Eisuke F.Sato,
Rumi Ishisaka,
Tomoko Kanno,
Tamotsu Yoshioka,
Tatsuji Yasuda,
Masayasu Inoue
and Kozo Utsumi		 FreeRad Res, inpress, 1998
Valinomycin Induces Apotosis of Ascites
Hepatoma Cells (AH-130) in Relation to
Mitochondrial Membrane Potential.		 Munehisa Yabuki,
Tomoko Kanno,
Jitsuo Akiyama,
Tatsuji Yasuda
and Kozo Utsumi		 Ce11Struct.Funct,
22,555-563		 1997
Mitochondrial Dysfunction in the Senescence
Accelerated Mouce (SAM).		 Hiroko Nakahara,
Tomoko Kanno,
Yoko Inai,
Kozo Utsumi,
Midori Hiramatsu,
Akitane Mori
and Lester Packer		 Free Rad. BioL Med.
24,85-92		 1997
Molecular Mechanisms of Apoptosis in HL-60 Cells
Induced by a Nitric Oxide- Releasing Compound.		 Munehisa Yabuki,
Shinji Kariya,
Yoko Inai,
Keisuke Hamazaki,
Tamotsu Yoshioka,
Tatsuji Yasuda,
Alan A. Horton
and Kozo Utsumi		 FreeRad. Res,
27, 325-335		 1997
前骨髄性白血病細胞ＨＬ-60のapotosisにおける
磁場暴露効果の検討		 井内腸子,中原裕子,
竹原良記,秋山実男，
内海耕慥		 日本物療医学研究会､
日本磁場生物学研究会､
研究事業平成8年度
研究報告書,105-115		 1997
Do Reactive Oxygen Species Underlie the
Mechanism of Apotosis in the Tadpole TaiI		 Hideki Hanada,
Akihiko Kashiwagi,
Yoshiki Takehara,
Tomoko Kanno,
Munehisa Yabuki,
Junzo Sasaki,
Masayasu Inoue
and Kozo Utsumi		 Free Rad, BioL Med.
23, (2), 294-301,		 1997
Oxigen-Dependent Fragmentation of Cellular
DNA by Nitric Oxide.		 Munehisa Yabuki,
Yoko Inai,
Tamotsu Yoshioka,
Keisuke Hamazaki,
Tatsuji Yasuda,
Masayasu Inoue
and Kozo Utsumi		 FreeRad.Res.26,245-255, 1997
Ｎｏによるミトコンドリア機能の可逆的阻害　
特に生理的低酸素下での作用を中心として		 竹原良記, 井内陽子,
矢吹宗久，秋山実男,
吉岡保, 井上正康,
内海耕慥		 Free Radicals in Clinical
Medicine フリーラジカルの
臨床11,95-I00，		 1997
細胞及ぴオルガネラ機能に対する
磁場暴露効果の検索		 井内陽子, 中原裕子,
竹原良記, 秋山実男,
吉岡保, 内海耕慥		 日本物療医学研究会､
日本磁場生物学研究会､
研究事業平成7年度
研究報告書		 1996
Oxygen-Dependent Reversible Inhibition of
Mitochondrial Respiration by Nitric Oxide		 Yoshiki Takehara,
Hiroko Nakahara,
Yoko Inai,
Munehisa Yabuki,
Keisuke Hamazaki,
Tamotsu Yoshioka,
Masayasu Inoue,
Alan A. Horton
and Kozo Utsumi		 Cell Struct. Funct.
21, 251-258,		 1996
Oxygen-Dependent Inhibition of Neutrophil
Respiratory Burst by Nitric Oxide.		 Shigehisa Iha,
Kunzo Orita,
Tomoko Kanno,
Toshihiko Utsumi,
Eisuke F.Sato,
Masayasu Inoue,
and Kozo Utsumi		 Free Rad, Res.
25, (6), 489-498,		 1996
Regulation of Neutrophil Superoxide Generation by
alpha-Tocopherol in Human Peripheral and
Umbilical-Cord Blood.		 Masaaki Ando,
Tamotsu Yoshioka,
Jitsuo Akiyama
and Takafumi Kudo		 J.Obstet. Gynaecol. Res.
22, (5), 507-516,		 1996
Oxygen-Dependent-Regulation of Ehrlich Ascites
Tumor Cell Respiration by Nitric Oxide.		 Yoshiki Takehara,
Munehisa Yabuki,
Eisuke F.Sato,
Jitsuo Akiyama,
Tatsuji Yasuda,
Masayasu Inouc,
Alan A.Horton
and Kozo Utsumi		 Cell Struct. Funct.
21, 151-157,		 1996
ＮＯの生物作用とその酸素濃度による調節１９９６ 竹原良記,井内陽子,
矢吹宗久,菅野智子,
内海耕慥　		 組織培養 22,(4),144-150 1996
α-tocopheroIおよびubiquinonｅによる
好中球刺激応答性活性酸素生成の阻害Ⅰ９９６		 菅野智子,竹原良記,
井内陽子,秋山実男,
吉岡保,内海耕慥		 ビタミンＥ研究の進歩6，
ビタミンＥ研究会編,81-86，		 1996
Inhibition of Neutrophil-Superoxide Generation by
α-Tocopherol and Coenzyme Q.		 Tomoko Kanno,
Toshihiko Utsumi,
Yoshiki Takehara,
Akio Ide,
Jitsuo Akiyama,
Tamotsu Yoshioka,
Alan A. Horton,
and Kozo Utsumi		 Free Rad. Res,
24, (4), 281-289,		 1996
2,2’-Azobis-（2-amidinopropane）
dihydrochIoride（ＡＡＰＨ）による生体膜機能の障害		 菅野智子,秋山実男,
竹原良記,西原利冶,
吉岡保,内海耕慥		 過酸化脂質研究
19,(2),169-172		 1995
Inhibition of Neutrophil Superoxide Generation by
Hypericin, an Antiretroviral Agent		 Tomoko Kanno,
Toshifumi Nishiuchi,
Takahiko Utsumi,
Jitsuo Akiyama,
Yoshiki Takehara,
Hirotsugu Kobuchi,
Tamotsu Yoshioka,
Alan A. Horton,
Tatsuji Yasuda
and Kozo Utsumi		 Arch. Biochem. Biophys,
323, (2) 335-342,		 1995
好中球のスーパーオキサイド生成と
ピタミンＥによる阻害		 菅野智子,竹原良記,
小渕浩嗣,中原裕子,
秋山実男,安藤正明,
吉岡保,内海耕慥		 ビタミンＥ研究の進歩5，
ピタミンＥ研究会編,132.138，		 1995
AAPHによるリポソームの区画性低下に及ぼす
トコフェロールの影響		 竹原良記,小渕浩嗣,
菅野智子,保田立二,
秋山実男,吉岡保,
内海耕慥		 ビタミンＥ研究の進歩5，
ビタミンＥ研究会編,87-92，		 1995
Oxygen-Dependent Regulation of Mitochondrial
Energy Metabolism by Nitric Oxide.		 Yoshiki Takehara,
Tomoko Kanno,
Tamotsu Yoshioka,
Masayasu Inoue
and Kozo Utsumi		 Arch. Biochem. Biophys.
323, (1) 27-32,		 1995
Effect of the Antiretroviral Agent Hypericin on Rat
Liver Mitahondria.		 Takahiko Utsumi,
Minoru Okuma,
Tomoko Kanno,
Yoshiki Takehara,
Tamotsu Yoshioka,
Yuhzo Fujita,
Alan A. Horton
and Kozo Utsumi		 Biochem. Pharmacol.
501 (5), 655-662,		 1995
Selective Inhibition of Human TNF-α Action by
Flecainide Acetate, an Antiarrhythmic Drag.		 Hirotsugu Kobuchi,
Toshiji Saibara,
Tatsuji Yasuda
and Kozo Utsumi		 physioL Chem, Phys.
& Med. Nm 27, 77-89,		 1995
Inhibition of Stimulus-Specific Neutrophil Superoxide
Generation by alpha-Tocopherol,		 Toshihiko Utsumi,
Hirotsugu Kobuchi,
Yosiki Takehara,
Jitsuo Akiyama,
Tamotu Yoshioka,
Alan A. Horton
and Kozo Utsumi		 FreeRad,Res.
22,(5),431-440		 1995
Light-Dependent Inhibition of Protein Kinase C and
Superoxide Generation of Neutrophils by Hypericin,
an Antiretroviral Agent.		 Takahiko Utsumi,
Minoru Okuma,
Toshihiko Utsumi,
Tomoko Kanno,
Tatsuji Yasuda,
Hirotsugu Kobuchi,
Alan A. Horton
and Kozo Utsumi		 Arch, Biochem. Biophys.
316, (1) 493-497,		 1995
Dysfunction of Mouse Liver Mitochondoria Inducede
by 2,2′-Azobis-(2-amidinopropane)dihydrochloride
(a Radical Initiator,AAPH) in the in vivo and in vitro
Systems,		 Tomoko Kanno,
Toshihiko Utsumi,
Akio Ide,
Yoshiki Takehara,
Toshiji Saibara,
Jitsuo Akiyama,
Tamotsu Yoshioka
and Kozo Utsumi		 FreeRad.Res.
21,(4),223-234		 1994